• Second governments can play an important part in

  2019-05-09

  

  Second, governments can play an important part in providing incentives for industry to invest in discovering new uses for old drugs. For example, it pkm2 could consider the extension of patent protection for old drugs that have found new uses, for example, as embodied in the Hatch-Waxman Act in the

• As long as developing world

  2019-05-09

  

  As long as developing-world health systems are ill prepared to offer safe anaesthesia and intensive care to patients in need of surgery, surgically treatable conditions will remain leading causes of death, the world will lose trillions of dollars in gross domestic product, and we in the global healt

• br In a detailed analysis using

  2019-05-09

  

  In a detailed analysis using multiple data sources in this issue of , Emily Keats and colleagues show that Kenya made some progress in reducing maternal and newborn mortality between 2003 and 2015, and made greater progress in reducing child mortality between 1998 and 2015, after earlier increases

• The diagnosis is very difficult on radiographical imaging al

  2019-05-09

  

  The diagnosis is very difficult on radiographical imaging alone as many tumours have similar radiological appearances to desmoplastic fibroma [2,7]. Biopsy is the gold standard method of determining the exact nature of any bony lesion as it provides a tissue diagnosis. The biopsy ideally should be p

• Upon diagnosis the patient s lymphoma and

  2019-05-08

  

  Upon diagnosis, the patient׳s lymphoma and HLH represented a therapeutic dilemma. Effective early therapy reduces mortality of HLH from 95% to 30–35% [4]. The HLH-2004 treatment protocol consists of T-cell targeted immunosupression with dexamethasone and cyclosporine, macrophage targeted etoposide

• dihydrofolate reductase In subgroup analysis of the types of

  2019-05-08

  

  In subgroup analysis of the types of hospice as classified by the administrative authorities (Table 3), there was a trend that the patients admitted to a public hospital had a higher rate of dying in a hospice than those admitted to a private hospital, especially in the military and veterans\' hospi

• The measurement of the PPI of DP

  2019-05-08

  

  The measurement of the PPI of DP following entrainment pacing usually consists of measuring the interval between the last capturing stimulus and the next DP. This technique is generally based on the assumption that, in the presence of 1:1 capture, pacing depolarizes the zone of slow conduction in th

• br Material and methods br Results br Discussion

  2019-05-08

  

  Material and methods Results Discussion Conclusion Financial support Conflicts of interest Introduction Metabolic syndrome comprises a cluster of conditions, including obesity, insulin resistance, hypertension, and abnormal cholesterol levels, which together increase cardiovascu

• El siguiente cap tulo Carlos Monsiv is

  2019-05-08

  

  El siguiente capítulo, “Carlos Monsiváis: el momento de reconstrucción”, se centra en varios ensayos de . Bajo la tutela de de Žižek, Ruisánchez se acerca al ensayo “Los días del temblor” quality control través de la escritura del trauma, una lectura que resulta particularmente reveladora y poco co

• br Aunque resulte dif cil creerlo la primera incursi

  2019-05-08

  

  Aunque resulte difícil creerlo, la primera incursión de Octavio Paz hacia el sur de América data de 1955, pero la aventura no lo llevó más allá de la isla de Santo Domingo, es decir, prácticamente a la misma latitud del Yucatán mexicano. Solo hasta abril de 1985 visitó por primera vez Argentina, i

• FGF is a member of

  2019-05-08

  

  FGF21 is a member of the FGF family. It is preferentially expressed in the liver and is inducible in adipose tissue. As an insulin-sensitizing metabolic regulator, it stimulates bch uptake by adipocytes and also targets the central nervous system. FGF21 treatment corrects diet-induced obesity in mic

• br Eva Leticia Ordu a Trujillo investigadora del en

  2019-05-08

  

  Eva Leticia Orduña Trujillo, investigadora del en uno de sus más recientes libros , aborda un tema fundamental para explorar, debatir y profundizar sobre nuestras aún muy débiles democracias latinoamericanas, order URMC-099 través de la actuación de nuestros estados en sedes judiciales internacion

• More than structural haemoglobin variants have been describe

  2019-05-08

  

  More than 900 structural haemoglobin variants have been described. Of these more than 100 show high oxygen affinity [2]. Erythrocytosis caused by Hb Ypsilanti was first described in 1967 [3], and the mutation results in substitution of amino harpagoside (β99 Asp→Tyr) involved in the stability of the

• br Discussion We were interested

  2019-05-08

  

  Discussion We were interested in knowing whether patients who were discharged before ANC recovery did well because they were younger, had better PS, or more likely to be in CR than patients who were not discharged before ANC recovery. However while patients with better PS (but not age) were more

• br Discussion In this pilot study we

  2019-05-08

  

  Discussion In this pilot study, we report that sequential treatment of low dose clofarabine and lenalidomide is safe and feasible for elderly patients with high risk MDS and AML. Only one subject developed dose limiting toxicity (liver dysfunction) from lenalidomide consolidation therapy. Pre-tre

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