• The underlying mechanisms of how

  2020-04-27

  

  The underlying mechanisms of how progesterone prolongs pregnancy, although not completely understood, are thought to have to do with reduction in uterine contractility, antimicrobial protein up-regulation, immunosuppression, and inflammatory inhibition. Specific to preterm PROM, progesterone has bee

• Drug resistance to both pathogens and cancer has

  2020-04-27

  

  Drug resistance to both pathogens and cancer has been a big hindrance in healthcare. Integrated research undertakings are being pursued to find the exact causes of the lack of response towards drugs. Surprisingly, host pumps are the key factors in failure of most drugs. The pumps either do not allow

• somatostatin agonist The inhibition of CYP activity by NOR w

  2020-04-27

  

  The inhibition of CYP11β activity by NOR was 11- and 2.5-fold higher than those reported for the antifungal agents ketoconazole (IC50: 4.4μM) and clotrimozole (IC50: 1.0μM) (Fernandes and Porte, 2013). Furthermore, NOR was able to inhibit P450 aromatase activity in carp ovaries, although at a rather

• br The interaction network between

  2020-04-27

  

  The interaction network between the lncRNAs which have been obtained from the previous steps, VDR and ESR was depicted using Cytoscape tool. Moreover, LncMAP tool (Li et al., 2018) was used to show transcriptional regulatory effects of two lncRNAs (MALAT1 and TBX5-AS1). The interaction network dep

• Enolase is an example of a moonlighting

  2020-04-27

  

  Enolase is an example of a moonlighting protein that displays multiple biological actions, including plasminogen, laminin, fibronectin, mucin and cytokeratin binding properties. It has also been described as a complement-evasion protein and as a protein capable of inducing neutrophil trap formation.

• In an effort to discover additional GPCRs directing the migr

  2020-04-27

  

  In an effort to discover additional GPCRs directing the migratory events of responding B cells, we identified Epstein-Barr virus (EBV)-induced gene 2 (EBI2) as a promising candidate. The gene encoding EBI2 (Ebi2, also known as Gpr183) was originally identified together with Ebi1 (Ccr7) as the most h

• Ubiquitination can occur on a single monoubiquitination or

  2020-04-27

  

  Ubiquitination can occur on a single (monoubiquitination) or several (multiubiquitination) lysine residues, or the same lysine residue can be subjected to several rounds of Ub conjugation (polyubiquitination). Ub bonds within polyUb chains are formed through 1 of 7 lysine residues in Ub, and the typ

• MuRF interacts with four and a half

  2020-04-26

  

  MuRF3 interacts with four-and-a-half LIM domain (FHL2) and γ-filamin leading to their degradation via UPS [64]. Conversely, abnormal aggregation of these proteins was observed in mice lacking MuRF3. Moreover, MuRF3-/- mice were found more prone to cardiac rupture after acute myocardial infarction (A

• Collagen compaction and alignment are generated by cell medi

  2020-04-26

  

  Collagen compaction and alignment are generated by cell-mediated contractile forces (Stopak and Harris, 1982). The transmission of actomyosin forces to collagen has been mainly attributed to integrins and the activation of the Rho-ROCK pathway (Clark et al., 2007, Kural and Billiar, 2013, Provenzano

• The mechanism by which these

  2020-04-26

  

  The mechanism by which these HIV-PIs impair skeletal muscle palmitate transport and oxidation has been partially elucidated. CD36 (also referred to as fatty ursolic acid translocase; FAT) is a transmembrane protein involved in the transport of long-chain fatty acids (LCFA) across cellular membranes.

• Nitric oxide synthase NOS is a

  2020-04-26

  

  Nitric oxide synthase (NOS) is a predominant enzyme of immune system, which elaborates nitric oxide (NO) from the amino IFN-alpha 1, human recombinant protein arginine (Arg). NO mediates vasodilatation, blood pressure regulation, neurotransmission, host defense, and macrophage-mediated immunity, am

• In conclusion we have found that Egr

  2020-04-26

  

  In conclusion, we have found that Egr1 can play an inhibitory role on DBH promoter-driven transcription. This inhibition requires a newly identified Egr1 response SB505124 at the −227/−224 region of DBH promoter. This inhibition appears to result from Egr1 directly bound to the DBH promoter. We spe

• DA neurons are capable of somatodendritic and axonal DA rele

  2020-04-26

  

  DA neurons are capable of somatodendritic and axonal DA release, which may occur at synapses, as well as non-synaptic or asynaptic sites (Trudeau et al., 2014). DA may also be released at different timescales and in response to different DA neuron firing patterns (Grace et al., 2007). Furthermore, s

• br Conclusion br Conflict of

  2020-04-26

  

  Conclusion Conflict of interest Introduction The sexual exploitation and internal trafficking of British children within the UK has received growing public and policy attention in recent years. This has largely been in response to a number of high profile police investigations into cases in

• br Acknowledgements br Introduction Lung cancer treatment

  2020-04-26

  

  Acknowledgements Introduction Lung cancer treatment strategies, especially molecular targeted therapy, have progressed rapidly. However, most established treatments are for adenocarcinoma of the lung, not for squamous cell carcinoma (SQCC). SQCC constitutes approximately 30% of lung cancers, w

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