• In this study we investigated whether the

  2020-08-05

  

  In this study, we investigated whether the Ednra signaling is involved in Hoxa9/Meis1-mediated leukemogenesis. We found an upregulation of Ednra in leukemic murine bone marrow (BM) Bradykinin acetate mg overexpressing Hoxa9 and Meis1 compared to cells overexpressing Hoxa9 alone. We showed that overe

• WNV a member of the genus Flavivirus within the

  2020-08-05

  

  WNV, a member of the genus Flavivirus within the family Flaviviridae, was first isolated in 1937 from a febrile woman in the West Nile region of Uganda (Brinton, 2002). Until 1999, WNV was mainly confined to Southern Europe, the Middle East, Africa, West and Central Asia, Indonesia and Australia. In

• We proposed a model for the ginsenoside Rb Rb Rc

  2020-08-05

  

  We proposed a model for the ginsenoside Rb1, Rb2, Rc, Rd, Re, and Rg1 inhibition of the ubiquitin–proteasome pathway (Fig. 5). Ginsenosides Re and Rg1 induced protein accumulation by blocking the first step of ubiquitination, which is ubiquitin-E1 activation. Ginsenosides Rb1 and Rd inhibited the ch

• Group B phytocystatins are also expressed in

  2020-08-05

  

  Group B phytocystatins are also expressed in caryopses. Although their expression patterns during germination are similar to those of the group A inhibitors, their expression patterns during seed development vary, indicating that they play different roles in the latter process. The highest levels of

• trabectedin br Epigenetic targeting Since Ewing sarcoma is a

  2020-08-05

  

  Epigenetic targeting Since Ewing sarcoma is a transcription factor driven disease, agents that target chromatin structure would be expected to have activity in this tumor type. In addition, a variety of protein complexes involved in the regulation of chromatin structure have been shown to be dysr

• Similarly research ranking RESEARCH was not significant in

  2020-08-04

  

  Similarly, research ranking (RESEARCH) was not significant in the model so H7 is not supported. Contrary to the findings of Bline et al., 2016b, Boone et al., 2006, the current study did not find an association between faculty research productivity and exam pass rate. This could be due to difference

• The lack of significant effects on serum and tissue choleste

  2020-08-04

  

  The lack of significant effects on serum and tissue cholesterol levels, or cholesterol and bile acid synthesis in Villin-Tgif1 fed a chow diet may also be due to a pathway termed transintestinal cholesterol efflux (TICE) [34]. Cholesterol is excreted by biliary secretion but can, at least in mice, a

• Selective inhibitor of phosphodiesterase type PDE I is

  2020-08-04

  

  Selective inhibitor of phosphodiesterase type 5 (PDE5I) is commonly used for ED treatment. PDE5I exhibits its vasodilatory effect by inhibiting the degradation of cyclic guanosine monophosphate (cGMP), which relaxes the smooth muscle and allows increased blood flow for penile tumescence. Udenafil (D

• In addition to the radioligand displacement assay

  2020-08-04

  

  In addition to the radioligand displacement assay, an ERRγ-RIP140 HTRF (FRET) assay was utilized to measure changes in coactivator interaction caused by compound treatment. A basal level of interaction between ERRγ and a peptide fragment from NR cofactor RIP140 was observed in the absence of added l

• br Materials and methods br

  2020-08-04

  

  Materials and methods Results Discussion In papillary thyroid carcinoma, ET-1 production and antagonism of ETAR have been demonstrated in human thyroid cancer CEP-37440 lines [22]. Endothelin 1 or ETAR has been only investigated at the tissue level for thyroid cancer in 2 research groups. L

• br Conclusion The results presented herein indicate that lar

  2020-08-04

  

  Conclusion The results presented herein indicate that large peptides were generated earlier than small sequences during GE hydrolysis of α-caseins. Furthermore, incubation temperature had an important effect in promoting the hydrolysis. The time for the iTRAQ-labelling process needs to be optimis

• Indirubin A growing number of other post translational

  2020-08-04

  

  A growing number of other post-translational modifications are implicated in regulation of the ubiquitin system, including substrate modification by hydroxylation, glycosylation, acetylation, methylation, modification by poly(ADP-ribose) (PAR), and attachment of ubiquitin-like modifiers. The HIF1-α

• Despite the important role of ubiquitination dependent mecha

  2020-08-04

  

  Despite the important role of ubiquitination-dependent mechanisms in DSB repair (Jackson and Durocher, 2013), UbL73P displayed no global defects in DNA repair mechanisms following bleomycin treatment or ionizing radiation, perhaps because UbL73P was incompletely utilized or because the need for deub

• br The emerging role of DNA PK in

  2020-08-04

  

  The emerging role of DNA-PK in the homeostasis of cell proliferation Besides the important roles of DNA-PK in DNA repair, radiation sensitivity and inflammatory response, Sul group has demonstrated that DNA-PK is involved in the transcriptional regulation of lipogenic genes during fasting/feeding

• 3280 receptor These findings are of great importance

  2020-08-04

  

  These findings are of great importance to the aging field because they uncover a novel mechanism by which accumulation of DNA damage leads to functional decline during aging. The role of DNA damage in aging has been a subject of debate (Campisi and Vijg, 2009). Clearly, artificially increased levels

15497 records 792/1034 page Previous Next First page 上5页 791792793794795 下5页 Last page