• br Action of GPR in metabolically

  2022-06-13

  

  Action of GPR55 in metabolically active tissues In addition to being highly expressed by discrete brain regions, as described in Section 2, GPR55 is also expressed in a wide range of peripheral tissues, including spleen, adrenals and bone (Sawzdargo et al., 1999, Ryberg et al., 2007, Whyte et al.

• To apply the recently developed GPR ligands to CNS

  2022-06-13

  

  To apply the recently developed GPR35 ligands to CNS disorders, it is necessary to understand whether GPR35 is expressed by any identified cell types in the 5-Iodotubercidin receptor and whether activation or blockade of this receptor has any consequence on the activity of the neuronal circuitry. T

• Although it is currently unknown why

  2022-06-13

  

  Although it is currently unknown why the longer splice variant found in the human has not been found in any other species, similar results have been reported for other receptors, including the plk inhibitor receptor splice variant ERbeta2 identified in human and primate, but not other species (Siere

• Bax inhibitor peptide V5 As the material for in silico

  2022-06-13

  

  As the material for in silico experiments we used an amino Bax inhibitor peptide V5 sequence of a fragment of HIV1 surface glycoprotein gp120 corresponding to its less mutable B-cellular epitope: NMWKNNMVEQMHEDIISLWDQ. This sequence is the same as the sequence of the NQ21 and the biotin-NQ21 peptide

• br Materials and methods br Results shows serum

  2022-06-13

  

  Materials and methods Results shows serum FSH, LH, oestradiol and progesterone values in the two cycles from day 2 to day 10. Basal values of these hormones on day 2 (before any intervention) were similar in the two cycles. Thereafter, FSH values did not differ significantly between the two c

• Materials and methods Standard curve for

  2022-06-13

  

  Materials and methods Standard curve for methylglyoxal. Different concentrations (10, 25, 50, and 100μM) of pure MG (Sigma) were derivatized with 1,2-diaminobenzene and the absorbance of the resulting derivative was read by Cary 50 Bio UV-Visible spectrophotometer (Varian). One milliliter of total

• KU-0063794 receptor In this study we find that DH CBD induce

  2022-06-13

  

  In this study, we find that DH-CBD induces analgesic effects on inflammatory but not acute pain and the KU-0063794 receptor level of spinal α1 GlyRs increased after CFA paw injection. These results suggest that GlyR α1 is only involved in chronic pain. A possible explanation is that once the expres

• Functional studies based on patch clamp electrophysiology pr

  2022-06-13

  

  Functional studies based on patch-clamp electrophysiology provide additional information on the active state of GlyR α1. Current-voltage measurements from single Nogo-66 (1-40) in outside-out patches at symmetric 145-mM chloride concentration yielded a unitary conductance of 86 pS for the main open

• ICH induced striatal lesion produced a reduction of EAAT exp

  2022-06-13

  

  ICH-induced striatal lesion produced a reduction of EAAT1 expression analogous to the decreased glutamate uptake at 6 h. The combined reduction of excitatory amino stock aee transporters and of glutamate uptake activity might explain the well-known glutamate excitotoxicity following brain ischemia

• Caffeine decreased EAAT and EAAT expression levels in P frac

  2022-06-13

  

  Caffeine decreased EAAT1 and EAAT2 dapagliflozin mg levels in P2 fraction, as well as [3H]d-aspartate uptake; however, as soon as caffeine is removed from incubation, [3H]-d-Aspartate uptake is recovered to control levels, eliminating the possibility of caffeine as a cell death inducer. In resume,

• In the liver ghrelin has opposite effects to

  2022-06-13

  

  In the liver, ghrelin has opposite effects to insulin on the expression of the enzyme PEPCK, thereby promoting gluconeogenesis and also causing a decrease in glucose uptake and fatty 74 9 oxidation (Rigault et al., 2007). Ghrelin also stimulates hepatic lipogenesis de novo in a GH-independent fashi

• br Conflicts of interests br Acknowledgements We thank Drs

  2022-06-10

  

  Conflicts of interests Acknowledgements We thank Drs. T. Tomita and T. Iwatsubo (Tokyo University, Tokyo, Japan) for anti-presenilin 1-CTF antiserum, Dr. A. Takashima (Gakushuin University, Tokyo, Japan) for anti-Pen-2 antiserum and the laboratory members for helpful comments and discussion. M

• br Materials and methods br Results br Discussion

  2022-06-10

  

  Materials and methods Results Discussion In this study, we identified a novel AMP scolopendrasin X from Scolopendra subspinipes mutilans through genome analysis. Scolopendrasin X stimulated neutrophil activity, resulting in calcium increase, chemotactic migration, and superoxide anion produ

• This excellent tolerability is especially

  2022-06-10

  

  This excellent tolerability is especially interesting in the light of the fact that intravenous administration of liposomal ponatinib was predicted to yield much higher plasma concentrations as compared to the orally administered free drug. In addition, liposomal drug dose in absolute numbers was te

• Despite the central role of mitochondria

  2022-06-10

  

  Despite the central role of mitochondria in oxidative metabolism, it remains unclear whether mitochondria play a central role in ferroptosis. Supporting this possibility, ferroptosis is associated with dramatic morphological changes of mitochondria, including mitochondrial fragmentation and cristae

15142 records 387/1010 page Previous Next First page 上5页 386387388389390 下5页 Last page