• Furthermore the immunoassays described in our study

  2022-06-24

  

  Furthermore, the immunoassays described in our study showed excellent concordance of more than 93.33% with the LAg-Avidity EIA (Table 2). Using a panel of samples obtained from HIV-1 seroconverters over the course of up to 602 days post-infection, the gp41 peptide-based MP3 or MP4 assay identified s

• Mammals adapt to prolonged periods of food scarcity by relea

  2022-06-23

  

  Mammals adapt to prolonged periods of food scarcity by releasing FFAs from adipose tissue and transforming them into energy-rich ketone bodies that are used as fuel by brain, muscle, and other organs (Kersten, 2014, Grabacka et al., 2016). Ketogenesis occurs primarily in hepatocytes, but its rate is

• In autoimmune diseases lymphocytes penetrate into the inflam

  2022-06-23

  

  In autoimmune diseases, lymphocytes penetrate into the inflammatory lesions of tissues, where it is prominently hypoxic or even anoxic, and utilize glycolysis for an energy supply after activation or under hypoxia (Sitkovsky and Lukashev, 2005; Palazon et al., 2014), which is modulated by the oxygen

• ddhGTP structure CD CD belong to the costimulatory

  2022-06-23

  

  CD80/CD86 belong to the costimulatory adhesion molecule family, which can activate T ddhGTP structure by the costimulatory pathway and have been used as indicators of DC maturation in numerous studies. In addition, MHC-II, as the principal component of antigen presentation, was significantly elevat

• br STAR Methods br Acknowledgments We thank Prof

  2022-06-23

  

  STAR★Methods Acknowledgments We thank Prof. Y. Tomari at the University of Tokyo for experimental advice and K. Hanada for technical assistance. This research was supported by Grants-in-Aid for Scientific Research on Innovative Areas “Nascent Chain Biology” (JP15H01548 and JP17H05677 to T.I. a

• There are five subfamilies of P

  2022-06-23

  

  There are five subfamilies of P-type ATPases (I-V), which transport metal ions or phospholipids across membranes (Palmgren and Nissen, 2011). Although our studies indicate that the P-type ATPase domain is important for function, how it contributes to cGMP production is currently unknown. The P-type

• b12 500 mg Our results show furthermore that higher concentr

  2022-06-23

  

  Our results show furthermore, that higher concentrations of butyric b12 500 mg additionally affect GSTP1 mRNA stability leading to a strongly reduced half-life. Concentration-dependent effects of butyric acid on RNA stability and cell signaling pathways involved in the regulation of GSTP1 expressio

• GPR and TRPV co localized in small

  2022-06-23

  

  GPR35 and TRPV1 co-localized in small- and medium-diameter DRG neurons. Nociceptive (Aδ- and C-fiber) neurons expressing TRPV1 mediate hyperalgesia, neurogenic inflammation, and neuropathic pain [12]. The cAMP-protein kinase A (PKA) dependent modifications of TRPV1 currents have been demonstrated in

• Finally the formation of a regular network of

  2022-06-23

  

  Finally, the formation of a regular network of fusion glycoproteins in their post-fusion state is not exclusive of vesiculovirus G. More or less regular networks have been also observed with other class III fusion glycoproteins such as pseudorabies gB [85] and several class II fusion glycoproteins [

• br Conclusion Until recently astrocytes were

  2022-06-23

  

  Conclusion Until recently, astrocytes were recognized solely for their maintenance role in the regulation of Coumarin australia homeostasis. Nowadays, this idea has changed, it is clear that these cells play a crucial role in the regulation of neuronal activity and signal transmission. In partic

• Expression and translocation of GLUT are

  2022-06-23

  

  Expression and translocation of GLUT4 are regulated by various mechanisms including protein kinase C isoforms (PKCs) and mitogen-activated protein kinase (MAPK) signals [22], [23], but the real mechanism that statins alter expression and function of GLUT4 has not been fully identified. It is general

• In a previous paper we demonstrated immunohistochemically th

  2022-06-22

  

  In a previous paper, we demonstrated immunohistochemically the Protease Inhibitor Cocktail (EDTA-Free, 100X in DMSO) of GHSR-1a in acrosomes and peripheral region of spermatid heads as well as in acrosomes of the spermatids undergoing spermiation [19]. The present study was undertaken to demonstrat

• Some malignant human tumors cells also express FPRs and

  2022-06-22

  

  Some malignant human tumors Coenzyme Q10 also express FPRs and respond to bacterial or endogenous agonists by increased motility and growth. For instance, FPRs expressed by human gastric cancer cells, mediate epithelial–mesenchymal transition, cell proliferation, migration, and resistance to apopto

• Several transgenic and knockout congenic mouse models

  2022-06-22

  

  Several transgenic and knockout/congenic mouse models have been generated in order to assess the role of FFAR1 for proper insulin secretion and maintenance of glucose homeostasis. The results obtained with three different receptor knockout mouse models were not consistent. The protection against hig

• br Importance of iron and lipoxygenase in

  2022-06-22

  

  Importance of iron and lipoxygenase in ferroptosis What remains to be somewhat controversial is the role of iron and lipoxygenases (LOX) in the death process, specifically in lipid peroxidation. So far, iron chelators have been repeatedly shown to halt ferroptosis (hence its name) induced by chem

15142 records 379/1010 page Previous Next First page 上5页 376377378379380 下5页 Last page