• In conclusion AXL overexpression preexisted in a subgroup of

  2023-11-30

  

  In conclusion, AXL overexpression preexisted in a subgroup of treatment-naive lung adenocarcinoma specimens harboring an activating EGFR mutation or in those with wild-type EGFR. Anti-AXL therapeutics delivered up front in combination with the EGFR inhibitor might overcome intrinsic or acquired resi

• The SKOV and SKOV TR cells were exposed

  2023-11-30

  

  The SKOV3 and SKOV3TR 4EGI-1 were exposed to stepwise increased concentration of paclitaxel with or without a different concentration of autophagy inhibitor (3-MA or HCQ) to further evaluate whether suppression of autophagy affected the growth and drug sensitivity of ovarian cancer cells in vitro.

• br Results br Discussion The

  2023-11-30

  

  Results Discussion The A. nidulans Aurora kinase displays diverse locations during mitosis and we show here that it also locates to hyphal regions where septa subsequently form, to the septal pore region of newly formed septa and displays a osi sc 175 specific location to mature septa. To inv

• The overall mechanism of the Cdc

  2023-11-30

  

  The overall mechanism of the Cdc48 complex resembles that of the 19S regulatory subunit of the proteasome, which also uses receptor proteins to bind polyubiquitin chains attached to a substrate and employs a translocation mechanism (for review, see Kish-Trier and Hill, 2013). As with Cdc48, full sub

• Otilonium Bromide br Experimental br Results and discussion

  2023-11-30

  

  Experimental Results and discussion Conclusion Acknowledgments This work is supported by the National Basic Research Program of China (973 Program 2016YFA0201201 and 2013CB932702), a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAP

• The class C receptors also share a common agonist binding

  2023-11-30

  

  The class C receptors also share a common agonist-binding mode. In all cases, an agonist induces VFT closure by forming intermolecular bonds with surface residues in both the LB1 and LB2 domains (Geng et al., 2013, Geng et al., 2016, Kunishima et al., 2000, Muto et al., 2007, Nuemket et al., 2017, T

• br Introduction Hepatocellular carcinoma HCC is an

  2023-11-30

  

  Introduction Hepatocellular carcinoma (HCC) is an aggressive and malignant cancer detected in clinical practice, as it is the third key reason of tumor-related deaths worldwide, with > 800, 000 mortalities every year (Torre et al., 2015). Current treatments for HCC are surgical therapy, liver tra

• Lomerizine HCl br Introduction Active oxygen radicals in the

  2023-11-30

  

  Introduction Active oxygen radicals in the human body have a strong effect of inducing lipid peroxidation, which in turn induces oxidative imbalance and causes various diseases. Natural polysaccharides are substances with certain antioxidant activity. They are used as antioxidants and have advant

• Amyloid fibrils are insoluble high molecular weight non crys

  2023-11-29

  

  Amyloid fibrils are insoluble, high-molecular-weight, non-crystalline aggregates and traditional experimental techniques for structure determination such as X-ray and solution NMR cannot resolve their high resolution structures [64], [68]. However, amyloid fibrils exhibit various advantageous featur

• How do increased levels of ammonia as

  2023-11-29

  

  How do increased levels of ammonia as observed in clinical HE constrain synaptic plasticity? Numerous studies have investigated the modulation of signal transduction pathways activated in LTP or LTD irrespective of being necessary or sufficient for changes in synaptic efficacy (Wen et al., 2013). Ye

• Another research group assessed pairs of middle aged years a

  2023-11-29

  

  Another research group assessed 8503 pairs of middle-aged ( monozygotic and 124 dizygotic same-sex twin pairs with and without history of surgery, respectively. Twins who underwent major surgeries scored slightly worse on cognition tests compared with those who had not undergone any intervention; ho

• Interest in natural products has led to the

  2023-11-29

  

  Interest in natural products has led to the study of plant extracts as sources of ARIs. However, chemical complexity of natural extracts makes the identification of ARIs challenging and time-consuming. Identification of bioactive compounds with the desired biological effect from natural products, co

• fludarabine A previous study showed that miR c

  2023-11-29

  

  A previous study showed that miR-200c is involved in glucose-mediated pathological processes (Zhang, Guan, & Jin, 2017). Glucose metabolism is critical for the growth and proliferation of both normal fludarabine and cancer cells, and reprogramming glucose metabolism now has been considered as a tar

• Tirapazamine br Adenosine as a mediator of procedures used t

  2023-11-29

  

  Adenosine as a mediator of procedures used to manage pain The issue of caffeine Caffeine, from dietary sources, is perhaps the most widely consumed behaviorally active agent in the world (Fredholm et al., 1999). Initial characterization indicated caffeine had a higher affinity at A1−, A2A− and

• br Clinical realities br Commentary on uses of

  2023-11-29

  

  Clinical realities Commentary on uses of selective 17,20 lyase inhibitors If continued monitoring of these same parameters along with tracking of circulating ACTH in human trials confirms these new drugs are the long sought after 17,20 lyase inhibitors, then we may for the first time be able t

15461 records 228/1031 page Previous Next First page 上5页 226227228229230 下5页 Last page